2016
Tran, H. N.; Karamitros, M.; Ivanchenko, V. N.; Guatelli, S.; McKinnon, S.; Murakami, K.; Sasaki, T.; Okada, S.; Bordage, M. C.; Francis, Z.; Bitar, Z. El; Bernal, M. A.; Shin, J. I.; Lee, S. B.; Barberet, Ph.; Tran, T. T.; Brown, J. M. C.; Hao, T. V. Nhan; Incerti, S.
Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation Journal Article
In: Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, vol. 373, pp. 126–139, 2016, ISSN: 0168-583X.
Abstract | Links | BibTeX | Tags: Geant4-DNA, Nanoparticle, Proton beam, Radiation therapy, Radiolysis
@article{tran_geant4_2016,
title = {Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation},
author = {H. N. Tran and M. Karamitros and V. N. Ivanchenko and S. Guatelli and S. McKinnon and K. Murakami and T. Sasaki and S. Okada and M. C. Bordage and Z. Francis and Z. El Bitar and M. A. Bernal and J. I. Shin and S. B. Lee and Ph. Barberet and T. T. Tran and J. M. C. Brown and T. V. Nhan Hao and S. Incerti},
url = {https://www.sciencedirect.com/science/article/pii/S0168583X16000653},
doi = {10.1016/j.nimb.2016.01.017},
issn = {0168-583X},
year = {2016},
date = {2016-04-01},
urldate = {2021-09-07},
journal = {Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms},
volume = {373},
pages = {126--139},
abstract = {Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170MeV, which are of interest for clinical proton therapy.},
keywords = {Geant4-DNA, Nanoparticle, Proton beam, Radiation therapy, Radiolysis},
pubstate = {published},
tppubtype = {article}
}
Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170MeV, which are of interest for clinical proton therapy.