Maryam Rahbaran

M.Sc. Student 
Medical Physics Unit
Department of Oncology

Novel Brachytherapy Technology

Bio

Maryam is a Master’s student in Dr. Enger’s lab. She has a B.Sc. in Combined Honours Physics and Astronomy from The University of British Columbia.

Current Projects

Development of a Software Package for Monte Carlo-based Intravascular Brachytherapy Dosimetry
Each year, cardiovascular diseases claim the lives of more people in the United States than chronic lung disease and cancer combined. The most common form of cardiovascular disease is coronary artery disease (CAD). CAD is commonly treated with a percutaneous transluminal coronary angioplasty (PTCA), where a small deflated balloon is led to a blocked section of an artery, then is inflated to create an opening. Typically drug-eluting stents (DES) are left behind to keep the artery open and slowly deliver medication to prevent in-stent restenosis (ISR). ISR is caused by metal stents putting stress on the arterial wall resulting in tissue damage and thus neointimal hyperplasia. Plaque is overproduced, which may result in narrowing the opening once again. Intravascular brachytherapy (IVBT) was the main course of treatment when only bare metal stents were used before DES were introduced in the early 90’s. IVBT consists of beta-emitting radionuclide seeds inside of a catheter-based device delivering radiation to stop neointimal hyperplasia at the lesion site. Treatment planning for IVBT is limited as AAPM task group 43, 60, and 149 base dose prescription off of dosimetry in a homogenous water phantom. However, our Monte-Carlo based studies have shown that heterogeneities such as the guidewire of the IVBT device, calcification, and metal stents significantly attenuate dose. The aim of this project is to use optical coherence tomography images from the Brigham and Women’s Hospital in Boston, Massacheusetts to perform Monte-Carlo simulations to quantify the dose attenuation of patient-specific heterogeneities compared to water calculations. 

2023

Rahbaran, Maryam; Kalinowski, Jonathan; Tsui, James Man Git; DeCunha, Joseph; Croce, Kevin; Bergmark, Brian; Devlin, Philip; Enger, Shirin A.

Development Of a Novel Dosimetry Software for Patient-specific Intravascular Brachytherapy Treatment Planning on Optical Coherence Tomography Images Presentation

22.06.2023, (2023 American Brachytherapy Society (ABS) Annual Meeting, Vancouver, Canada).

BibTeX

2022

Rahbaran, Maryam

Graduate Excellence Award award

2022.

Abstract | BibTeX

Rahbaran, Maryam; Kalinowski, Jonathan; Tsui, James Man Git; DeCunha, Joseph; Enger, Shirin A.

Monte-Carlo Based Simulations of the Uncertainties in Clinical Water-Based Intravascular Brachytherapy Dosimetry Presentation

11.04.2022.

Abstract | BibTeX